You may or may not want to have comments on your site. Set up the settings on this page as you wish, but if you have comments then be sure the options mentioned below are unchecked. Failing to do this will encourage your site to be spammed.
That said, to minimise form spam, make sure you've installed the Cloudflare plugin mentioned on my WordPress plugin recommendations page.
If allowing comments, I prefer to set all comments to manual approval. Otherwise you leave yourself open to spam or derogatory/embarrassing comments on your site. This will be a huge pain though if you get a lot of comments. I think comments are less expected than they used to be and really are just an invitation to spam. My advice would be to switch them off altogether.
Go To Dashboard → Settings → Discussion.
To turn off comments altogether simply ensure this option is unchecked.
Please note that this will not turn off any existing comments, only those on new posts. But if you are building a Seed site then there should be no existing posts of comments if you've followed the steps.
Also do the following whether you are allowing comments or not.
Make sure the following options are unchecked.
If you are allowing comments, make sure one of the following options is checked.
The other options on this page are up to you.